Zyprexa as anti-emetic

Olanzapine (Zyprexa) is an antipsychotic in the thienobenzodiazepine class that blocks multiple neurotransmitters in brain. Olanzapine, relieves nausea in some patients failing to respond to the usual antiemetics. Studies have shown the effectiveness of olanzapine as an antiemetic. Olanzapine combined with a single dose of dexamethasone and a single dose of palonosetron is found to be very effective in controlling acute severe nausea.


Olanzapine as an Antiemetic in Refractory Nausea and Vomiting in Advanced Cancer - Journal of Pain and Symptom Management, Volume 25, Issue 6, Pages 578-582 (June 2003)